河北医科大学：《天然药物化学》课程教学资源（讲稿）改变世界的分子 Molecules that Changed the World（2019，1/5）

“新发现使生活更美好” 科学创造价值，分子改变世界

MOLECULES THAT CHANGED THE WORLD K.C.NICOLAOU.T.MONTAGNON

Molecules That Changed The World' The molecules to be discussed include the following: Urea &Acetic Acid Amphotericin B Glucose. Gingkolide Aspirin ycosporin,FK506&Rapamycin Camphor Calicheamicin Tropinone Palytoxin Haemin Taxol Morphine Mevacor,Zaragozic Acids&The CP Molecules Steroids&The Pill Brevetoxin B Strychnine Ecteinascidin 743 Penicillin Epothilones Longifolene Resiniferatoxin Prostaglandins Vancomycin Vitamin B Quinine Erythronolide Band Erythronolide A Thiostrepton Monensin Small Molecule Drugs Avermectin Biologics

Chemistry in Our Life OH SUGAR CHANGED OH THE WORLD A Slory ofag Spice.Slnetx Frecdom.ad Scicnee OH SY MARC ARONSON AND MARINA BUDHOS 大07 OH Sucrose OH

Chemistry in Our Life Vitamin B12 Is Vital to Maintain Healthy H2NOC -CONH2 Brain- H2NOC CONH2 Spinal cord Red blood cells H2NOC CONH2 SUNDOWN CLEAN B12 1000 mcg VITAMIN B12 HO Depression Anemia Brain Shrinkage

Chemistry in Our Life Ascorbic Acid (Vitamin C) HO 1A其A5C MALICODE HO. COOH CO( H HCH HCH HCOH L-抗坏血酸 H COOH CO Albert Szent-Gyorgyi HO OH 1893-1986 Vc之父1937NP Vitamin C cures colds?

生物碱的渊源 The Beginning of Scientific Pharmacy Journal of ETHNO- PHARMACOLOGY 之 Friedrich Serturner 那些科学家为生物碱做出了杰出贡献？ 著名的生物碱有哪些化合物？ Alkaloids:Nature's Curse Or Blessing? Roots of modern pharmaceutical chemistry

Who is the father of alkaloids HO Quinine 1820 Pierre Pelletier 1788-1842Fran 石榴皮碱 Pelletierin Pseudopelletierin Colchicine 1820 Strychnine 1818

Gentlemen Who Invented Pharmacy 150th anniversary of discovery of quinine Cinchona bark and quinine sulphate in pharmacy Stamp Pelletier and Caventou Note Malari parasite formula Stamp-Frae nda,1970 Stamp-Rwandese 1970

Definition of alkaloid "In general,it seems appropriate to me to Il.Ueber ein neues PAanzenalkali impose on the known plant substances not CAIkaloid). the name "alkalis"but "alkaloids",since vom they differ greatly in some properties from Dr.W.M e if s n e r. the alkalis:among the chapters of plant chemistry,they would therefore find their Journal fuir Chemie und Physik, place before plant acids fsince "Alkaloid" vol.25,pp.377-381,1819, would precede "Saure"(acid)." Title of Meissner's article in which he coined the word alkaloid'in 1819 and his reasoning for the choice of this word. Carl Friedrich Wilhelm Meissner (1792-1853)received a PhD in 1815.In l8l9 he took over a pharmacy in Halle,and discovered veratrin(藜芦碱 (Veratridine)