复旦大学：《基因组学》课程教学资源（课件讲稿）第00章 基因组学导论（主讲：杨金水、罗小金）

基因组学”导 论

“基因组学”导 论

人类基因组测序计划 背景与现状简介

人类基因组测序计划 ------背景与现状简介

人类基因组测序计划一创议与实施 1第一阶段:酝酿 2)第二阶段:论证 3)第三阶段:实施

人类基因组测序计划--创议与实施 1)第一阶段: 酝酿 2)第二阶段: 论证 3)第三阶段: 实施

人类基因组计划的酝酿星星之火 1984年12月,在美国犹他州盐湖城滑雪胜地阿 尔他,由美国能源部资助的一次环境诱变和致 癌物防护国际会议上,到会代表在讨论中提 出了一个问题:在受辐射伤害的人群中,能检 测到突变的比率比预期低三分之二.有什么新 办法可以非常有效地,直接地检测出人类基因 的突变?或者说,有没有新方法可在日本广岛, 长崎原子弹爆炸后的幸存者及其子女的群体 中直接测定基因突变? 这是生物科学家首次讨论人类基因组计划

人类基因组计划的酝酿—星星之火 1984年12月,在美国犹他州盐湖城滑雪胜地阿 尔他,由美国能源部资助的一次环境诱变和致 癌物防护国际会议上, 到会代表在讨论中提 出了一个问题:在受辐射伤害的人群中,能检 测到突变的比率比预期低三分之二.有什么新 办法可以非常有效地,直接地检测出人类基因 的突变?或者说,有没有新方法可在日本广岛, 长崎原子弹爆炸后的幸存者及其子女的群体 中直接测定基因突变? 这是生物科学家首次讨论人类基因组计划

盐湖城A北a会议一起点1984 Alta is a ski area nestled amons the Wasatch Mountains(note Original text said saguache Mountains) in Utah, Salt Lake City. From December 9 to 13, 1984 The Alta meeting was sponsored by the Department of Energy doe) and the international commission for Protection against Environmental mutagens and TOWN OF ALTA Carcinogens. It was initiated by David smith of doe and mortimer Mendelsohn of the lawrence Livermore National laboratory

盐湖城Alta会议—起点,1984 Alta is a ski area nestled among the Wasatch Mountains (note: Original text said Saguache Mountains) in Utah, Salt Lake City. From December 9 to 13, 1984. The Alta meeting was sponsored by the Department of Energy (DOE) and the International Commission for Protection Against Environmental Mutagens and Carcinogens. It was initiated by David Smith of DOE and Mortimer Mendelsohn of the Lawrence Livermore National Laboratory

英雄所见略同 $5年5月,在加州大学圣搭克鲁兹分校举行的次非正式生 物会议上,该校名誉校长 bert sinsheimer提出是否有可能将人类 基因组的所有顺序都測出来参加会以的有哈佛大学诺贝尔 奖得6C)的1mb的hta受此启发, 规发起一个大基因组测序计划6t并没想了具体的安排 Walter Gilbert. A crucial early proponent he later tried to set up a company to produce and sell genome data

英雄所见略同 Walter Gilbert. A crucial early proponent, he later tried to set up a company to produce and sell genome data

Santa cruze会议, California,1985 Robert l sinsheimer: the University of California, Santa Cruz During a Critical Decade 1977-1987Sinsheimer was appointed chancellor(分校校长) by uc President David Saxon in June, 1977. Formerly chairman of the division of biology at the California Institute of Technology (CIa )where his work as a molecular biologist had earned him a distinguished international reputation

Santa Cruz会议, California,1985 Robert L. Sinsheimer: The University of California, Santa Cruz, During a Critical Decade, 1977-1987Sinsheimer was appointed chancellor(分校校长) by UC President David Saxon in June, 1977. Formerly chairman of the division of biology at the California Institute of Technology (CIA )where his work as a molecular biologist had earned him a distinguished international reputation

1984年之前分子生物学 技术的主要进展 1)1953年DNA双螺旋模型发表. 2)1968年纯化第一个限制酶 3)1972年第一个重组DNA分子面世 4)1973年SV40病毒DNA限制酶物理 图发表 5197发明DNA序列测序法

1984年之前分子生物学 技术的主要进展 1) 1953年DNA双螺旋模型发表. 2) 1968年纯化第一个限制酶. 3) 1972年第一个重组DNA分子面世. 4) 1973年SV40病毒DNA限制酶物理 图发表. 5) 1977年发明DNA序列测序法

Santa Fe会议,新墨哥州1986 Charles delisi(Boston University) DOE ASSociate Director for health and Environmental research in the mid-1980s was one of 28 hon- orees to whom President bill Clinton presented the presidential Citizens Medal on January 8, 2000. Charl s LeLisi Dawid A Smith According to the award citation, Delisi was the first government scientist to conceive and outline the feasibility, goals, and parameters of the Human Genome Project. David smith is a founder and current Director of the doe Human genome Program 10 Following the santa fe conference. doe ohER announces human Genome Initiative. With $5.3 million, pilot projects begin at DOE national laboratories to develop critical resources and technologies

Santa Fe 会议, 新墨哥州,1986 Charles DeLisi (Boston University), DOE Associate Director for Health and Environmental Research in the mid-1980s, was one of 28 hon￾orees to whom President Bill Clinton presented the Presidential Citizens Medal on January 8, 2000. According to the award citation, DeLisi was the first government scientist to conceive and outline the feasibility, goals, and parameters of the Human Genome Project. David Smith is a founder and current Director of the DOE Human Genome Program.  Following the Santa Fe conference, DOE OHER announces Human Genome Initiative. With $5.3 million, pilot projects begin at DOE national laboratories to develop critical resources and technologies

推波助澜杜贝克宣言 1986年,1975年医学和生理学诺贝尔奖得主 美国 Salk Institute研究所癌症研究员杜贝 可( Renato dulbecco)在“ Science”上发表题 为“癌症研究的转折点:定出人类基因组序 列”一文,引起了美国社会大众的广泛关注, 并使基因组测序计划的支持者和反对者进 行了一场为时数年的争论 杜贝可提出了两条基因搜寻路线: 1)DNA测序;2)基因组作图

推波助澜—杜贝克宣言 1986年, 1975年医学和生理学诺贝尔奖得主, 美国Salk Institute研究所癌症研究员杜贝 可(Renato Dulbecco)在“Science”上发表题 为“癌症研究的转折点:定出人类基因组序 列”一文, 引起了美国社会大众的广泛关注, 并使基因组测序计划的支持者和反对者进 行了一场为时数年的争论. 杜贝可提出了两条基因搜寻路线: 1) DNA测序; 2) 基因组作图