《病理学》课程教学资源（PPT课件）chapter 1 病理学绪论 Pathology（2/2）

Metaplasia化生Definition:Metaplasia is areversiblechange inwhichoneadult cell typeisreplaced byanotheradult cell type-种分化成熟的细胞为另一种分化成熟的细胞所替代的过程，是存在于正常组织中的干细胞或结缔组织中未分化间叶细胞通过增生转变，即重新程序化的结果化生只出现于具有增生能力的细胞特异性低的细胞取代特异性高的细胞化生只发生于同源细田胞之间BasementNormalReserveSquamousmembranecolumnarcellsmetaplasiaepitheliumA

Logo Metaplasia is a reversible change in which one adult cell type is replaced by another adult cell type. Metaplasia 化生 一种分化成熟的细胞为另一种分化成熟的细胞 所替代的过程。 ⚫ 是存在于正常组织中的干细胞或结缔组织中未分化间叶细胞通 过增生转变，即重新程序化的结果 ⚫ 化生只出现于具有增生能力的细胞 ⚫ 特异性低的细胞取代特异性高的细胞 ⚫ 化生只发生于同源细胞之间 Definition:

Metaplasia-TypesEpithelialmetaplasiaSquamousmetaplasiacolumnarepithelium(trachea,cervix,cholecyst鳞状上皮化生transitionalepithelium(pelvis)IntestinalmetaplasiaGastricglandularepithelium肠上皮化生Pseudo-pyloricglandMetaplasiacorpus and sinusgastricgland假幽门腺化生MesenchymalmetaplasiaOsseous,cartilageandadiposetissuemetaplasiaFibroblasts骨、软骨、脂肪组织化生Logo

Logo Metaplasia-Types Epithelial metaplasia Mesenchymal metaplasia columnar epithelium (trachea, cervix, cholecyst) transitional epithelium (pelvis) Squamous metaplasia 鳞状上皮化生 Intestinal metaplasia 肠上皮化生 Gastric glandular epithelium Pseudo-pyloric gland Metaplasia 假幽门腺化生 corpus and sinus gastric gland Osseous, cartilage and adipose tissue metaplasia 骨、软骨、脂肪组织化生 Fibroblasts

Metaplasia-Types子宫颈鳞状上皮化生【Squamousmetaplasiaofcervix】Logo

Logo Metaplasia-Types

Metaplasia-TypesnormalSquamous metaplasia具Logo

Logo Metaplasia-Types Squamous metaplasia normal

正常气管上皮鳞状上皮化生Logo

Logo 正常气管上皮 鳞状上皮化生

Metaplasia-TypesLogo

Logo Metaplasia-Types Squamous metaplasia

Metaplasia-Typesvilliof normal tracheasquamousmetaplasia

Logo squamous metaplasia villi of normal trachea Metaplasia-Types

Metaplasia-Types胃粘膜肠上皮化生（Intestinalmetaplasiaofstomach】左侧为胃体腺，右侧可见吸收细胞、杯状细胞、潘氏细胞。Logo

Logo Metaplasia-Types

Metaplasia-significanceMetaplasia---a“"double-edged sword"Advantage→DefendinglossofnormalfunctionDisadvantageCancertransformationNormalReserveBasementSquamouscellscolumnarmembranemetaplasiaepitheliumALogo

Logo Advantage loss of normal function Cancer transformation Disadvantage Metaplasia-significance Metaplasia-a “double-edged sword” Defending

AdaptationIncreaseddemandsGrowthstimulationhypertrophyhyperplasiaadaptationatrophymetaplasiaDiminishednutritionChronicstimulationLow stimulationPathologicalLogo

Logo atrophy hypertrophy hyperplasia metaplasia adaptation Adaptation Increased demands Growth stimulation Diminished nutrition Low stimulation Chronic stimulation Pathological