《皮肤性病学》课程教学资源（PPT课件）梅毒 Sexually Transmitted Diseases（STD）

Sexually Transmitted Diseases (STD)

Sexually Transmitted Diseases (STD)

·Syphilis Gonorrhea Nongonococcal Urethritis Condylomata Acuminata Genital Herpes Acquired Immunodeficiency Syndrome (AIDS) 。Chancroid Lymphogranuloma Venereum

• Syphilis • Gonorrhea • Nongonococcal Urethritis • Condylomata Acuminata • Genital Herpes • Acquired Immunodeficiency Syndrome （AIDS） • Chancroid • Lymphogranuloma Venereum

Syphilis A contagious,sexually transmitted disease Cutaneous and internal organic lesions Caused by the spirochete Treponema palidum A potentially lifelong disease

Syphilis • A contagious, sexually transmitted disease • Cutaneous and internal organic lesions • Caused by the spirochete Treponema palidum • A potentially lifelong disease

pathogeny It is caused by Treponema pallidum The syphilis bacterium is very fragile This organism causes infection when it penetrates broken or abraded skin or mucous membranes

pathogeny • It is caused by Treponema pallidum • The syphilis bacterium is very fragile • This organism causes infection when it penetrates broken or abraded skin or mucous membranes

Transmission 1.Intimate sexual contact with infectious lesions. most common,>95% untreated patient 2. transplacental passage during the later stages of pregnancy (4 months) -congenital syphilis 3.blood transfusions 4.Indirect contact kiss,suckle,infectant

Transmission 1. Intimate sexual contact with infectious lesions, most common, >95% untreated patient 2. transplacental passage during the later stages of pregnancy (4 months) - congenital syphilis. 3. blood transfusions 4. Indirect contact kiss, suckle, infectant

Stages in the disease ·Acquired syphilis 。Congenital syphilis ·Early syphilis Late syphlis

Stages in the disease • Acquired syphilis • Congenital syphilis • Early syphilis • Late syphlis

Acquired syphilis (1).Primary syphilis:chancre, 1.Early regional lymphadenopathy syphilis (2).Secondary syphilis:syphilids (2 years) (3).Early latent syphilis:positive STS, without detectable clinical manifestations,normal spinal fluid 2.Late syphilis (1).Tertiary syphilis:destructive lesions (>2 years) (2).Late latent syphilis

1. Early syphilis ( 2 years) (1). Primary syphilis: chancre, regional lymphadenopathy (2). Secondary syphilis: syphilids (3). Early latent syphilis: positive STS, without detectable clinical manifestations, normal spinal fluid (1). Tertiary syphilis: destructive lesions (2). Late latent syphilis Acquired syphilis

Congenital syphilis 1.Early congenital syphilis (2 year old)

Congenital syphilis 1. Early congenital syphilis ( 2 year old)

Clinical manifestation Acquired syphilis

Clinical manifestation Acquired syphilis

Primary syphilis 。Main symptom (1).Chancre the first cutaneous lesion,direct inoculation (2).Enlargement of neighboring glands

Primary syphilis • Main symptom (1). Chancre - the first cutaneous lesion, direct inoculation (2). Enlargement of neighboring glands