上海交通大学：《药理学 Pharmacology》课程教学资源（讲义课件）抗肿瘤药物药理

上海充通大学 Shanghai Jiao Tong Univer.. 抗肿瘤药物药理 2010.12

抗肿瘤药物药理 2010.12

上浒充通大￥ 讨论题 Shanghai Jiao Tong University 从不感冒者得癌症的机会大，还是易 患感冒者得癌症机会大？ 过敏发生率，发达国家发生率高，还 是贫困国家高？

Shanghai Jiao Tong University 讨论题 从不感冒者得癌症的机会大，还是易 患感冒者得癌症机会大？ 过敏发生率，发达国家发生率高，还 是贫困国家高？

上游文通大学 Shanghai Jiao Tong University 生物学上“僭越效应”。 僭越：超越本分 “不干不净，吃了没病”。一定病菌刺激可以使 人体免疫系统功能增强 过敏发生率：发达国家儿童发生率高于贫困国家 金丝桃受到一定刺激后，其中的抗抑郁成分金丝 桃苷含量会增加 从不感冒者易患癌症(5倍)， 因为感冒促使干 扰素产生。 砷剂少量应用，促白细胞分化，治疗白血病

Shanghai Jiao Tong University 生物学上“僭越效应” 。 僭越：超越本分 “不干不净，吃了没病” 。一定病菌刺激可以使 人体免疫系统功能增强。 过敏发生率：发达国家儿童发生率高于贫困国家 金丝桃受到一定刺激后，其中的抗抑郁成分金丝 桃苷含量会增加 从不感冒者易患癌症（5倍），因为感冒促使干 扰素产生。 砷剂少量应用，促白细胞分化，治疗白血病

上游充通大￥ Shanghai Jiao Tong University 人为什么会生癌？ :人体：~1000万亿个细胞 病毒、霉菌、射线、化学致癌剂；遗传因素；免 疫功能低下..直接、间接影响DNA >3000万个癌变细胞，可能成为癌症 Women who inherit a single defective copy of either of the tumor suppressor genes BRCA1 and BRCA2 have a significantly increased risk of developing breast cancer

Shanghai Jiao Tong University 人为什么会生癌 人体：～1000万亿个细胞 病毒、霉菌、射线、化学致癌剂; 遗传因素；免 疫功能低下……直接、间接影响DNA >3000万个癌变细胞，可能成为癌症 Women who inherit a single defective copy of either of the tumor suppressor genes BRCA1 and BRCA2 have a significantly increased risk of developing breast cancer. 人为什么会生癌?

上游充通大 Cancer 后 Shanghai Jiao Tong University Cancer is a disease characterized by a shift in the control mechanisms that govern cell survival,proliferation,and differentiation. 1.uncontrolled proliferation 2.dedifferentiation(去分化)and loss of function 3.invasiveness 4.metastasis（转移)

Shanghai Jiao Tong University Cancer Cancer is a disease characterized by a shift in the control mechanisms that govern cell survival, proliferation, and differentiation. 1. uncontrolled proliferation 2. dedifferentiation（去分化） and loss of function 3. invasiveness 4. metastasis（转移）

上商充通大￥ What Is Metastasis? 1.Cancer cells Blood invade surrounding vessel tissues and vessels 2.Cancer cells are transported by the circulatory system to distant sites 3.Cancer cells reinvade and grow at new location

Shanghai Jiao Tong University

h 上商充通大￥ Shanghai Jiao Tong University Basic facts of cancer most common cause of death from disease (中 国第一位死因；死180万/年) morbidity getting higher gradually chemotherapy,some curative,mostly palliative almost all the anticancer drugs can be produced in China 国际抗癌联盟第21届世界抗癌大会，2010,8月18日-21 日，中国 2008,全球1270万人患癌，死760万

Shanghai Jiao Tong University Basic facts of cancer ü most common cause of death from disease （中 国第一位死因；死180万/年） ü morbidity getting higher gradually ü chemotherapy, some curative, mostly palliative ü almost all the anticancer drugs can be produced in China ü 国际抗癌联盟第21届世界抗癌大会，2010，8月18日-21 日，中国 ü 2008，全球1270万人患癌，死760万

上游充通大￥ 后 Shanghai Jiao Tong University One in seven people will be diagnosed with cancer during their lifetime. liver cancer lung cancer 2.6 million new cancer cases per year in China currently and the incidence is increasing rapidly due to longer life-span and change of life styles.一陈竺

Shanghai Jiao Tong University One in seven people will be diagnosed with cancer during their lifetime. liver cancer lung cancer 2.6 million new cancer cases per year in China currently and the incidence is increasing rapidly due to longer life-span and change of life styles. －陈竺

上浒文通大学 Causes of cancer Shanghai Jiao Tong University genetic predisposition:tumor suppressor genes deleted or damaged,etc. exposure to environmental carcinogens: radiation,chemicals (including ones in food), viruses(1/5癌症由慢性感染引起，如人类乳 头瘤病毒引起宫颈癌；乙肝病毒引起肝癌)，… In a healthy body immune system can recognize and destroy foreign cells.If .. √生活方式（吸烟；肥胖；）

Shanghai Jiao Tong University Causes of cancer ü genetic predisposition: tumor suppressor genes deleted or damaged, etc. ü exposure to environmental carcinogens: radiation, chemicals (including ones in food), viruses（1／5癌症由慢性感染引起，如人类乳 头瘤病毒引起宫颈癌；乙肝病毒引起肝癌 ）, … ü In a healthy body immune system can recognize and destroy foreign cells. If … ü 生活方式（吸烟；肥胖；…）

上游充通大￥ Shanghai Jiao Tong University radiotherapy chemotherapy free radicals replisome stalling alkylation environmental damage toxins replication UV light errors bulky adducts strand O-methyl breaks guanine pyrimidine dimers mismatches insertions/deletions

Shanghai Jiao Tong University