温州医学院：《临床微生物及微生物检验》课程教学课件（PPT讲稿）病毒学

Natural History of Hcv Infection 600, HCV Total Core Antigen Hepatocellular carcinoma 500 Acute hepatitis Chronic liver disease/ cirrhosis 400 Symptoms/signs 300 anti-HCV antibody △RNA( RT-PCR 200 100 Normal Weeks→ Months Years Decades

on to spend REVERSE DNA Provirus DNA TRAHSLATION Transport to Nucleus mRNA tamaran TRANSCRIPToN Caspxl Assembly

Hepatitis C Virus Genome capsid envelope protease/helicase RNA-dependent RNA polymerase proteins c22 33c c-100 core E1 NS2 NS3 NS4 NS5 hypervariable ISDR 3011 amino acids STRUCTURAL NON-STRUCTURAL

Natural History of Hcv Infection 600, HCV Total Core Antigen Hepatocellular carcinoma 500 Acute hepatitis Chronic liver disease/ cirrhosis 400 Symptoms/signs 300 anti-HCV antibody △RNA( RT-PCR 200 100 Normal Weeks→ Months Years Decades