《发酵与生物工程手册》（英文版）FERMENTATION AND

FERMENTATION AND BIOCHEMICAL ENGINEERING HANDBOOK Principles, Process Design, and Equipment Second edition Edited by Henry C. Vogel Consultant Scotch Plains, New Jersey and Celeste L. Todaro Heinkel Filtering Systems, Inc Bridgeport, New Jersey np Westwood, New Jersey, U.A

FERMENTATION AND BIOCHEMICAL E NG I N E E RI N G HANDBOOK Principles, Process Design, and Equipment Second Edition Edited by Henry C. Vogel Consultant Scotch Plains, New Jersey and Celeste L. Todaro Heinkel Filtering Systems, Inc. Bridgeport, New Jersey NOYES PUBLICATIONS Westwood, New Jersey, U.S.A. lnpl

Copyright o 1997 by Noyes Publications No part of this book may be reproduced or utilized any form or by any means, electronic or by any information storage and retrieval system, without permission in writing from the Publisher. of Congress Catalog Card Number: 96-29055 0-8155-14077 ublished in the United States of America 369 Fairview Avenue, Westwood, New Jersey 07675 10987654321 Library of Congress Cataloging-in-Publication Data Fermentation and biochemical engineering handbook - 2nd ed, / edited by Henry C. Vogel and Celeste L. Todaro Includes bibliographical references and index ISBN0815514077 I Biochemical engineering--Handbooks, manuals, 2. Fermentation-.Handbooks, manuals, etc. I. Vogel, Henry C. II. Todaro, Celeste L TP2483F741996 660.28449-dc20 96-29055

Copyright 8 1997 by Noyes Publications No part of this book may be reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording or by any information storage and retrieval system, without permission in writing from the Publisher. Library of Congress Catalog Card Number: 96-29055 Printed in the United States ISBN: 0-8 155-1407-7 Published in the United States of America by Noyes Publications 369 Fairview Avenue, Westwood, New Jersey.07675 10 9 8 76 5 43 2 1 Library of Congress Cataloging-in-Publication Data Fermentation and biochemical engineering handbook. -- 2nd ed. / edited by Henry C. Vogel and Celeste L. Todaro. p. cm. Includes bibliographical references and index. 1. Biochemical engineering--Handbooks, manuals, etc. ISBN 0-8155-1407-7 2. Fermentation--Handbooks, manuals, etc. I. Vogel, Henry C. 11. Todaro, Celeste L. TP248.3.F74 1996 660'.28449--d~20 96-29055 CIP

DEDICATION For my parents, Ernest and Charlotte Todaro whose pursuit of knowledge inspired me and to do

DEDICATION For my parents, Ernest and Charlotte Todaro, whose pursuit of knowledge inspired me and continues to do so

Contributors Michael J. Akers Edwin O. Geiger Eli Lilly and Company Pfizer inc Indianapolis, IN Groton. CT Giovanni bellin Stephen M. Glasgow 3V Cogeim S.P.A Union Carbide Chemical and South charleston, WV Ramesh R. Bhave U.s. Filter Corporation Elliott Goldberg Warrendale. PA Consultant Fort Lee. NJ Frederick j Dechow Biocryst Pharmaceuticals Inc Yujiro Harada Birmingham, AL K. F. Engineering Co, Ltd Tokyo, Japan Barry Fc OX Niro in Willem Kar Columbia. MD Louisiana State University Agricultu Howard L. Freese Baton Rouge, LA Allvac Monroe. Nc

Contributors Michael J. Akers Eli Lilly and Company Indianapolis, IN Giovanni Bellini 3V Cogeim S.P.A. Dalmine, Italy Ramesh R. Bhave U.S. Filter Corporation Warrendale, PA Frederick J. Dechow Biocryst Pharmaceuticals Inc. Birmingham, AL Barry Fox Niro Inc. Columbia, MD Howard L. Freese Allvac Monroe, NC Edwin 0. Geiger Pfizer Inc. Groton, CT Stephen M. Glasgow Union Carbide Chemical and Plastics Co., Inc. South Charleston, WV Elliott Goldberg Consultant Fort Lee, NJ Yujiro Harada K. F. Engineering Co., Ltd. Tokyo, Japan Willem Kampen Louisiana State University Agriculture Center Baton Rouge, LA

Contributors xi Mark Keyashian Shinsaku Takayama CENTEON Tokai University Shizuoka pref. J: John P. King Celeste L. Todaro Foxboro Company Heinkel Filtering Systems, Inc Bridgeport, NJ Maung K Min David B. Todd Gemini Management Consultants Todd Engineering New York, NY Princeton NJ James Y. oldshue Henry C. Vogel Mixing Equipment Co, Inc Consultant Rochester NY Scotch Plains. NJ Laura Pellegrini Mark r. walden politecnico di milano Eli Lilly Company Milano. ita Indianapolis, IN Russell t Roane Bechtel Engineering San Francisco, CA Kyowa Hakko Kogyo Co., Lt Tokyo, Japan Seiji Sa Sunto-gun, Shizuoka Pref, Japan Allan C Soderberg Fort Collins, cO Curtis S. Strother Eli Lilly Company Indianapolis, IN

Contributors xi Mark Keyashian CENTEON Kankakee, IL John P. King Foxboro Company Rahway, NJ Maung K. Min Gemini Management Consultants New York, NY James Y. Oldshue Mixing Equipment Co., Inc. Rochester, NY Laura Pellegrini Politecnico di Milano Milano, Italy Russell T. Roane Bechtel Engineering San Francisco, CA Kuniaki Sakato Kyowa Hakko Kogyo Co., Ltd. Tokyo, Japan Seiji Sat0 Kyowa Medex Co., Ltd. Sunto-gun, Shizuoka Pref., Japan Allan C. Soderberg Fort Collins, CO Shinsaku Takayama Tokai University Numazu, Shizuoka Pref., Japan Celeste L. Todaro Heinkel Filtering Systems, Inc. Bridgeport, NJ David B. Todd Todd Engineering Princeton, NJ Henry C. Vogel Consultant Scotch Plains, NJ Mark R. Walden Eli Lilly Company Indianapolis, IN Curtis S. Strother Eli Lilly Company IndianaDolis. IN

NOTICE To the best of our knowledge the information in this publication accurate; however the Publisher does not assume any responsibility or iability for the accuracy or completeness of, or consequences arising from, such information. This book intended for informational purposes only. Mention of trade names or commercial products does not constitute endorsement or recommendation for use by the Publisher. Final determination of the suitability of any information or product for use contemplated by any user, and the manner of that use,is the sole responsibility of the user. We recommend that anyone intending to rely on any recommendation of materials or procedures mentioned in this publication should satisfy himself as to such suitability, and that he can meet all applicable safety and health standards

NOTICE To the best of our knowledge the information in this publication is accurate; however the Publisher does not assume any responsibility or liability for the accuracy or completeness of, or consequences arising from, such infomation. This book is intended for informational purposes only. Mention of trade names or commercial products does not constitute endorsement or recommendation for use by the Publisher. Final determination ofthe suitability ofany information or product for use contemplated by any user, and the manner of that use, is the sole responsibility of the user. We recommend that anyone intending to rely on any recommendation of materials or procedures mentioned in this publication should satisfy himself as to such suitability, and that he can meet all applicable safety and health standards